Thursday, Novemb. 15. 1677. At a Meeting of the Coun­cil of the Royal Society

Ordered,

That a Book, entituled Experi­ments in Consort of the Luctation ari­sing from the Affusion of several Men­struum's upon all kinds of Bodies, ex­hibited to the Royal Society, April 13. and June 1. 1676. by Nehemiah Grew, M. D. Fellow of the R. S. be printed by John Martyn, Printer to the said Society.

Thomas Henshaw Vicepraeses S. R.

EXPERIMENTS IN CONSORT OF THE LUCTATION ARISING From the Affusion of several MENSTRUUMS Upon all sorts of Bodies. To which is added The Nature, Causes, and Power of Mixture. Exhibited to the Royal Society. By NEHEMIAH GREW, M. D. and Fellow of the Royal Society.

LONDON, Printed for John Martyn, Printer to the Royal Society, at the Bell in S. Pauls Church-yard. 1678.

EXPERIMENTS IN CONSORT OF THE LUCTATION Arising upon the Mixture of Bodies.

EXPERIMENTS IN CONSORT OF THE LUCTATION ARISING From the Affusion of several MENSTRUUMS Upon all sorts of BODIES, Exhibited to the Royal Society, April 13. and June 1. 1676. By NEHEMIAH GREW, M. D. and Fellow of the Royal Society.

LONDON, Printed for John Martyn, Printer to the Royal Society, at the Bell in S. Pauls Church-yard. 1678.

TO THE MOST ILLUSTRIOUS THE ROYAL SOCIETY, THE FOLLOWING EXPERIMENTS ARE MOST HUMBLY PRESENTED BY THE AUTHOR NEHEMIAH GREW.

THE PREFACE.

THE intent of the following Experiments is twofold. The one, To be as a De­monstration of the Truth of one, amongst other Pro­positions, laid down in my Discourse of Mixture, sc. That it would be a Key [Page] to let us easily into the knowledge of the Nature of Bodies.

The other, and that con­sequently, To be as a Spe­cimen of a Natural Hi­story of the Materia Me­dica: that is to say, a multifarious Scrutiny into the intrinsick Properties of all those Materials, which have been, or may be used in Medicine: for the per­formance whereof, the fol­lowing Method is exhibi­ted as one, amongst others, necessary to be insisted up­on. [Page] For what Dominion a Prince hath over the Mo­ral, that a Physician hath, as one of God Almighty's Vice-Roys, over the Cor­poreal World. Whence therefore nothing can more import, than a particular knowledge of the Genius of all his Subjects, those several Tribes of Matter, supposed to be under his Command.

The Experiments may seem too numerous to be of one make. But no less a number would have an­swered [Page] the design of an Universal Survey; which, though less pleasing, proves the more instructive in the end: not being like ang­ling with a single Hook; but like casting a Net a­gainst a shole; with as­surance of drawing up something. Besides the ad­vantage of comparing ma­ny together; which be­ing thus joyned, do often­times, like Figures, signi­fie ten times more, than standing alone, they would have done.

[Page] How far the Corolla­ries all along subjoyned have made this good, is left to the Reader to judge. And also, to add to them, so many more, as he plea­ses; for I make my own thoughts no mans Mea­sure. Those I have set down, if compared, will, I presume, appear easie and natural; which is all I shall say for them. Let them go and take their fortune without a Flam­beau; which being pre­fixed to things of so glim­mering [Page] a shew, would not serve to blazon, but extin­guish them.

[Page]EXPERIMENTS IN CONSORT OF THE LUCTATION Arising upon the Mix­ture of Bodies.

CHAP. I.

ALthough there are some known Ob­ervations of this nature; [Page 2] yet there is no Author, I think, who hath given us a Systeme of Experiments in consort upon the Subject: the performance where­of, therefore, is here in­tended.

The Bodies whereup­on I made tryal, were of all kinds, Animal, Vegeta­ble, and Mineral. Amongst Vegetables, such as these, scil. Date-stones, Ginger, Colocynthis, Pyrethrum, Hawthorn-stones, Staphis­agria, Euphorbium, the Arenulae in Pears, Semen [Page 3] Milii Solis, Tartar, Spirit of Scurvygrass, Spirit of Wine, &c.

Amongst Minerals, se­veral sorts of Earths, Stones, Ores, Metals, Sul­phurs, and Salts.

Amongst Animals; such as these, scil. Hairs, Hoofs, Horns, Shells and shelly Insects, Bones, Flesh, and the several Viscera, Silk, Blood, Whites and Yolks of Eggs, Sperma Ceti, Civet, Musk, Castor, Gall, Vrine, Dungs, ani­mal Salts and Stones.

[Page 4] The Liquors which I poured hereupon several­ly, were these, scil. Spirit of Salt Armoniac, Sp. of Harts-Horn, Sp. of Nitre, Aq. fortis, Oil of Salt, Oil of Sulphur, and Oil of Vi­triol.

In the mixture of these Bodies, two things, in ge­neral, are all along to be observed, viz.

First, which they are, that make any, or no Lu­ctation. For, as some which seem to promise it, make none: so, many, [Page 5] contrary to expectation, make a considerable one.

Next, the manner where­in the Luctation is made; being with much variety in these five sensible ef­fects.

1. Bullition; when the Bodies mixed produce only a certain quantity of froth or bubbles.

2. Elevation; when, like Paste in baking, or Barm in the working of Beer, they swell and huff up.

3. Crepitation; when [Page 6] they make a kind of his­sing and sometimes a crackling noise.

4. Effervescence; then only and properly so cal­led, when they produce some degree of heat.

5. Exhalation; when not only fumes, but visi­ble steams are produced.

Of all these, some­times one only happens, sometimes two or more are concomitant. Some­times the Luctation be­gins presently upon mix­ture, and sometimes not [Page 7] till after some intermissi­on. In some bodies, it continues a great while; in others, is almost instan­taneous: Examples of all which I shall now pro­duce; beginning with Vegetables, as affording the least variety.

And first, if we take Spirit or Oil of Salt, Oil of Vitriol, Spirit of Nitre, or Aq. fortis, and pour them severally upon the several parts of Vegetables, as Roots, Woods, Stones, &c. we shall find, that they are, [Page 8] generally far less apt to make a Luctation, than ei­ther Animal, or subterra­neal Bodies.

Whence, as from one argument, it seemeth evi­dent, That in most Vege­tables, and in most of their parts, the predomi­nant Salt is an Acid. But that, on the contrary, the predominant Salt in most Minerals, and parts of A­nimals, is an Alkaly: in the former, usually a fix­ed; in the latter, a vola­tile Alkaly.

[Page 9] Again, although the Luctation which most Ve­getables, and most of their parts make with Acids, be but small, yet some they make; especially with some Acids, as with Spirit of Nitre and Aqua fortis.

Whence it seemeth plain, That there is an Alkalizate Salt existent in many Vegetables, even in their natural estate; and that it is not made Alkali­zate, but only Lixivial, by the fire. Or, there is some quantity of a Salt, [Page 10] call it what we will, in the said Bodies, which is so far different from, as to make a Luctation with an Acid. But to give parti­cular instances of the se­veral proportions wherein it appears to be in several Vegetables.

And first, of all vegeta­ble Bodies, Date-stones are amongst the least apt to make a Luctation with A­cids, if they may be said to make any at all.

Hence they are not so potent Nephriticks, as ma­ny [Page 11] other Stones, which make a more sensible Lu­ctation.

Ginger makes a small Bullition with Aq. fortis, only observable by a Glass.

Hence the pungency of Ginger lyeth in a sulphu­reous and volatile Salt, which yet is very little Alkalizate.

Scurvygrass-seed makes a very small Bullition with Aq. fortis, like that of Gin­ger. So doth also the seed of Purslane.

Hence, although there [Page 12] is much more of a certain kind of volatile Salt in Ginger or Scurvygrass, than in Purslane; yet there is as much of an Alkaly in any one, as the others.

Colocynthis, Fruit-stones, the stony Covers of the seeds of Elder, white Bryony, Violets, and others, with Aq. fortis make a Bulliti­on just perceivable without a Glass.

Hence it appears, That the great Cathartick pow­er of Colocynthis lyeth not [Page 13] in an Alkaly, but an A­cid; as making a much less Bullition, than some other vegetable Bodies, which are less Cathartick. For which reason likewise it is, That the best Cor­rectors, or Refractors of the force of Colocynthis, are some kinds of Alka­lies, as particularly that of Vrine, as Riverius hath somewhere observed.

The Root of Pyrethrum, with Aq. fortis, makes a Bullition and huff, in a short time.

[Page 14] Hence, the Cause of a durable Heat, upon the Tongue, is an Alkalizate Sulphur. For the Heat of Ginger, though greater; yet abideth nothing near so long as that of Pelli­tory or Pyrethrum; which, as is said, maketh also a more sensible Bullition with Acids.

Kermes-berries, com­monly, but ignorantly, so cal­led, with the said Liquor, huff up to an equal height, but in a somewhat longer time.

[Page 15] Hence they are gently astringent; scil. as their Alkaly binds in with some preternatural Acid in the stomach.

Hawthorn-stones, with Aq. fortis, huff up equally with the former Body; but the Bullition is not so visi­ble. The like is also ob­servable of Medlar-stones.

Hence, as they contain a middle quantity of an Alkaly, they are not insig­nificantly used against the Stone.

Seeds of Staphisagria, [Page 16] with Aqua fortis, make a Bulliti [...]n still more visible. But it quickly ends.

This confirms what was said before, sc. That the cause of a durable Heat is an Alkalizate Sulphur; these Seeds producing a durable Heat, as doth the Root of Pyrethrum.

The seeds also of red Roses, Borage, and Com­frey do all with Aq. fortis make a considerable Bulli­tion and huff; and that ve­ry quickly.

So that amongst all [Page 17] Shells and Stones, those generally make the great­est Bullition, which are the hardest and the brit­tlest.

Euphorbium makes a Bullition yet more conside­rable, with much froth, and very quickly.

From which Experi­ment, compared with two of the former, it appears, That Euphorbium is not an acid, but an alkalizate Gum. As also, that the cause of its so very dura­ble Heat, is an alkalizate [Page 18] Sulphur, as of Pyrethrum and Staphisagria hath been said.

It seems also hence e­vident, that the power of all great Sternutatories ly­eth not in their Acid, but their Alkalies.

The Arenulae or little stones in Pears, cluster'd round about the Coar, with Aq. fortis, presently huff up, and make a great Bul­lition and Effervescence, much greater than do any of the Bodies above-na­med.

[Page 19] Whence, although, so far as I know, they have never yet been used in Medicine; yet is it pro­bable, that they are a more potent and effectual Nephritick, than any of the Bodies aforesaid, and some of them usually pre­scribed.

It is hence also mani­fest, That, according to what I have elsewhere First Book of the Anato­my of Plants. said, for the sweetening of the Fruit and Seed, the tartareous and [Page 20] alkalizate parts of the Sap are precipitated into their stones, stony parts, and shells.

The last Instance shall be in the shells of the seeds of Milium Solis; which not only with Aq. fortis, but some other Acids, make a greater and quicker Bul­lition and Effervescence, than any other vegetable Body, upon which I have yet made tryal, in its natu­ral estate.

Hence, as well as from divers of the last fore-go­ing [Page 21] Instances, we have a clear confirmation of what I have, towards the beginning of this Dis­course, asserted; sc. That there is an alkalizate Salt existent in Plants, even in their natural estate. As also, that they are as sig­nificantly used against the Stone, quatenus alkali­zate, as Millepedes, Egg­shells, or any other testa­ceous Bodies of the same strength.

To these I shall sub­joyn one or two Exam­ples [Page 22] of Vegetable Bodies which are more or less alter'd from their natural estate.

Neither Crystals of Tar­tar, nor Tartar it self (al­though they have some store of alkalizate mixed with their acid parts) make any Effervescence with Acids, but only with Alkalies, as Spirit of Harts Horn, &c.

Hence the calculous se­diment of Vrine, not so properly called the Tar­tareous part of the Vrine; [Page 23] from the quite contrary events following its mix­ture with the aforesaid Salts; as will be seen hereafter.

Spirit of Scurvygrass maketh no Luctation with any acid.

Hence (as from a for­mer Experiment was a­bove-noted) it seems, That there may be a kind of volatile Salt, which is neither acid, nor alkali­zate; such as this of Scur­vygrass and other like Plants seems to be: scil. [Page 24] such a Salt as is not pro­perly alkalizate, and yet contrary to an acid; as experience shews in its efficacy against the acid Scurvy.

Rectified Spirit of Wine, both with Spirit of Nitre, and with Oil of Vitriol, se­verally, maketh a little Luctation.

Which argues, that there is contained, even in this Spirit, some portion of a volatile Alkaly.

Spirit of Wine, and dou­ble Aqua fortis, as the [Page 25] strongest is called, make an effervescence so vehement, as plainly to boil.

Besides the vehemence hereof, there is another sur­prizing circumstance. For whereas all other Liquors which make an Efferve­scence together, will do it in any quantity assigned to either of them, although but one drop to a thousand: on the contrary, these two, sc. rectified Spirit of Wine and Aqua fortis, require a certain proportion the one to the other. For if into [Page 26] no more than six drops of Spirit of Wine you put in but two or three of Aq. for­tis, they stir no more than if you put in so much Water: but drop in about seven or eight drops of Aq. fortis, and they presently boil up with very great vehemen­cy.

Hence we may con­ceive the reason of the so very sudden access of an acute Disease, and of its Crisis. These not begin­ning gradually with the Cause; but then, when [Page 27] the Cause is arrived unto such an [...], or such a certain Proportion, as is necessary to bring Nature to the contest. And these may serve for Examples upon Vegetables.

CHAP. II.

HAving given seve­ral Instances of tryal upon Vegetables; I next proceed to Minerals, which, for some orders [Page 28] sake, I shall distribute into five or six sorts, sc. Earths, Stones, Ores and Metals, Sulphurs, and Salts.

First for Earths. Oil of Vitr. upon Fullers Earth, doth not stir it, or cause the least Bullition. Nor upon yellow Oker. Nor up­on the Oker which falls from green Vitriol. The same Oil of Vitr. and Spir. of H. Horn poured seve­rally upon Bolus Armena of two kinds, and upon one kind of Terra sigillata, stir none of them.

[Page 29] Hence Bolus's are the Beds, or as it were, the Materia prima, both of opacous Stones and Me­tals; into which the said Bolus's are transmuted, by being concentred with divers kinds of Salts and Sulphurs, which succes­sively flow in upon them.

Aqua fortis, and Oil of Vitr. being poured several­ly upon another sealed Earth, which was vended by the name of Terra Lem­nia; they both made a ve­ry considerable Efferve­scence [Page 30] herewith.

Whence it appears, That there is no small difference in the nature, and therefore the opera­tion of Bolus Armena and Terra Lemnia. As also, betwixt the sealed Earths themselves, one making a great Effervescence, ano­ther none at all. Where­to, those that use them, are to have regard.

Next for Stones. And first Spir. of Nitre upon Tripoly, stirreth it not in the least.

[Page 31] Irish Slate, with Spirit of Harts-horn, maketh a small, yet visible Bulliti­on: and it presently cea­seth. So that it seems to be nothing else but a Vitriolick Bole. As is also argued from its taste, which is plainly acid, and somewhat rough.

Whence also it is with good reason given upon any inward Bruises. Be­cause by coagulating the Blood, it prohibits its too copious afflux into the affected part. Yet being [Page 32] but gently astringent, and so the Coagulations it makes, not great; they are likewise well enough carried off from the same part in the Circulation; by both which means an Inflammation may be ei­ther prevented, or the better over-ruled.

Lapis Haematites ma­keth no Effervescence at all either with Alkalies or A [...]d [...].

[...] of the green part [...] Magnet with Oil of [...]itriol maketh some few [Page 33] bubbles, yet not visible without a Glass.

But the podwer of the black part of a Magnet, which is the said stone ful­ly perfect, stirreth not with any acid. Neither doth the calcined Magnet.

Hence there is some considerable difference betwixt Iron and the Ma­gnet.

Lapis Lazuli, with Oil of Vitriol, and especially with Spirit of Nitre, ma­keth a conspicuous Bulli­tion.

[Page 34] Hence its Cathartick virtue lyeth in an Alkaly. For which reason it is al­so appropriate, in like manner as Steel, to the cure of Hypochondriacal Affections; originated from some kind of fer­menting Acid.

Osteocolla, with Spirit of Nitre maketh yet a grea­ter Effervescence.

How it comes to be so great a knitter of bro­ken bones, as it is repu­ted, is obscure. It seem­eth, that upon its solu­tion [Page 35] by a Nitrous acid in the body; it is precipi­tated upon the broken part, and so becomes a kind of Cement thereto.

Lapis Tuthiae, with Spi­rit of Nitre, maketh an Effervescence much alike. And with Oil of Vitriol very considerably.

But Lapis Calaminaris with Oil of Vitriol grows stark; as the powder of Alabaster doth with water. With spirit of Nitre it ma­keth a little Bullition, and quickly. But with Aq. for­tis, [Page 36] a great one; beyond any of the stones above­named.

Hence both Tutty and Calamy are Ophthalmicks from their Alkaly. Which is also confirmed, from the efficacy of some Al­kalies of the like use.

Hence also Calamy see­meth to partake some­what of the nature of Sil­ver: as by tryal made upon that also, will here­after better appear.

Chalk and Oil of Sul­phur or Vitriol make as [Page 37] strong an Effervescence as any of the rest.

Whence it is some­times well used against a Cardialgia.

Whiting makes as great an Effervescence as Chalk. So that it seems the saline parts are not washed a­way with the water, wherein the Chalk, for the making of Whiting, is dissolved.

Talk will not stir in the least either with spirit of Nitre, or Cil of Vitriol.

But that which is called [Page 38] the Lead-Spar maketh a considerable Effervescence with both of them seve­rally.

Hence, however this be called English Talk, yet there is no small dif­ference betwixt this and true Talk.

To these stones may be added petrified bodies. As petrified wood; which (that upon which I made tryal) no acid stirreth in the least.

Petrified shells; upon four or five several sorts whereof Oil of Vitriol be­ing [Page 39] poured, produceth a great Effervescence.

The Root or rougher part of the Stone called Glossopetra, with spirit of Nitre, maketh a conspicu­ous Bullition.

Asteria, the Stone so called, and found in some places in England, with Oil of Vitriol, maketh an Effervescence at the same degree. So doth the Belem­nites, or Thunder-stone, both the larger and the les­ser kinds.

So that none of these [Page 40] are acid, or vitriolick, but alkalizate Stones.

Coralline, with Oil of Vitriol, makes a conspicu­ous Bullition, yet mild and gentle; that is, with very little, if any heat, and with­out any visible Fumes. And red and white Coral do the like.

Hence they are all of a very gentle operation, and fit for Children, as the case requires.

Magistery of Coral (pre­pared the ordinary way) stirreth not in the least, ei­ther [Page 41] with Alkalies or A­cids.

Whence it is evident, That its active Principles are in its preparation de­stroyed and washed a­way: that is to say, It is an elaborate Medicine good for nothing. And thus far of Stones.

I next come to Metals and Ores. And first for Lead; upon which spirit of Salt, spirit of Nitre, or Aq. fortis being dropped, it stirreth not in the least with any of them: but with [Page 42] Oil of Sulphur, and espe­cially with Oyl of Vitrio [...] it maketh a slow Bullitio [...] and froth.

Hence it seemeth to b [...] the most alkalizate Meta [...] Which is also confirme [...] by a foregoing Experi­ment upon the Lea [...] Spar, which maketh considerable Efferve­scence with any sort o [...] acid. And which likewise being calcined, yieldeth a good quantity of Lixi­vial Salt.

Lead-Ore stirreth not at [Page 43] all with Aq. fortis or Oil of Vitriol. But spirit of Salt makes it bubble, and spirit of Nitre makes it boil.

Hence there is a consi­derable difference be­twixt the perfect Metal and the Ore.

Burnt Lead and red Lead, make a very small Bullition with Oil of Vi­triol, with spirit of Nitre a far greater.

Mercury, with Oil of Vitriol, will not stir, nor with Oil of Sulphur. But with spirit of Nitre pre­sently boils up.

[Page 44] Hence Mercury is a sub­acid Metal; spirit of Ni­tre being a subalkaliza [...] Acid.

The filings of Iron o [...] Steel, with Oil of Vitriol make a fair Bullition, lik [...] that of Minium. But spirit of Nitre makes them boi [...] with much celerity.

Hence Iron is likewise a subacid Metal.

Steel prepared with Sul­phur maketh a far less Ef­fervescence with the same spirit of Nitre, than do the filings.

[Page 45] Hence there is a great difference in their strength. So that ten grains of the filings un­prepared, will go as far as fifteen grains or more of those which are prepa­red, as above-said. Yet [...]n some cases the weaker and milder may be the better.

There is one circumstance in the mixture of Steel and Aq. fortis, which is sur­prizing; and that is this, That strong Aqua fortis, dropped upon Steel, will [Page 46] not, of it self, make th [...] least Bullition: but if here to you only add a drop o [...] two of Water, they present­ly boil up with very gre [...] vehemency.

The cause is obscure yet it is well known, tha [...] Water it self will dissolv [...] Iron: so that it appears as well by this, as by som [...] other Experiments, tha [...] even in Water, as mild a [...] it is, there is some kind o [...] corrosive Principle.

Antimony with spirit o [...] Nitre, and Aq. fortis seve­rally, [Page 47] maketh an Efferve­scence; somewhat lower than Iron. With Oil of Vi­triol the Bullition is so small, as difficultly to be perceived with a Glass.

Hence it seemeth to be of a very compounded nature; if I may so call it, a subacido-alkalizate Metal.

Crocus Metallor. with spirit of Nitre, makes a very little Effervescence.

Whence the Metalline Salt is not wholly lost in the preparation, but only diminished.

[Page 48] Antimonium Diaphore­ticum, with Spirit of Nitre and Oil of Vitriol several­ly, makes a considerable Effervescence.

Wherefore it is not an useless Preparation; as from the Calcination and Ablution used therein, some have thought.

Bezoardicum Minerale, (that upon which I made tryal) stirreth not at all either with Alkalies or Acids.

To which, let those who make use of it, have regard.

[Page 49] Tin, with Spirit of Ni­tre, makes so hot and vehe­ment an Effervescence, that it turns presently, as it were, into a Coal. It makes also a fair Bullition with Oyl of Vitriol. And a gentle one with Spirit of Salt.

Wherefore it hath something of the nature both of Iron, Lead, and Copper.

The like remarkable circumstance is seen in the mixture of Aq. fortis with Tin, as with Iron. For Tin [Page 50] and Aqua fortis of them­selves will not stir; but add a few drops of Water to them, and they boil up with the greatest vehemen­cy.

Copper, with Spirit of Salt, and Oyl of Vitriol se­verally, stirs not at all. Spirit of Nitre, and Aqua fortis, both boil it up vehe­mently.

Neither Spirit of Harts-horn, nor Spirit of Salt Armoniac maketh any Bul­lition therewith. But both of them, by a gentle solu­tion, [Page 51] that is, gently separa­ting its Sulphur from its Salts, turn it blue.

Hence Copper hath a greater proportion of a­cid than any of the fore­mentioned Metals.

Silver neither with Spi­rit of Salt, nor Oyl of Vi­triol makes any Bullition. With Spirit of Nitre it makes one, but 'tis soon over: and then continues to dissolve slowly into white Coagulations. It also ma­keth with Spirit of Harts­horn, or of Salt Armoniac, [Page 52] a full and deep blue.

Hence there is a great­er proportion of acid in Silver, than in Lead, Mer­cury, Iron, Antimony, Tin, or Copper.

Litharge of Silver ma­keth the greatest Efferve­scence with Oyl of Vitriol. Yet some with Spirit of Ni­tre. And with Spirit of Salt Armoniac maketh some little huff or elevation. And being mixed with Spirit of Nitre and Spirit of Salt Armoniac both together, produceth a faint blue.

[Page 53] Hence, although the far greater part of this Litharge be but Lead; yet it seems it hath some small mixture of Silver. But that of Gold seemeth, for contrary reasons, not to have any Gold.

Gold maketh no Effer­vescence with any single Salt I know of. But it is commonly dissolved with Aqua Regis, which is known to be a very alkalizate Li­quor.

Whence it seemeth [...] ▪ That as Lead is the most [Page 54] alkalizate, so Gold the most acid of Metals.

These things conside­red, and other observati­ons added hereunto, may possibly give some dire­ctions, not only for the ordering and using, but even for the making, imi­tating and transmuting of Metals. Thus far of Me­tals.

I will next give one or two Instances of tryal upon Sulphurs. And first Sul­phur vive, with Aq. fortis, maketh an apparent Bulli­tion, [Page 55] but it is some time, before it begins. But the factitious or common Brim­stone, maketh scarce any, if any at all.

So that there is no small difference betwixt them.

White and yellow Arse­nick make no Bullition ei­ther with Alkalies or A­cids.

Wherefore the strength of its operation on the Body, lies more in a Sul­phur, than a Salt.

The ashes either of Pit-Coal, or Sea-Coal, make no [Page 56] Effervescence with Alka­lies or Acids.

Whence the saline Principle is altogether vo­latile, and sublimed away by the fire.

Lastly for Salts. And first of all, Borax maketh no Effervescence nor any Fumes with Oyl of Vitriol or Spirit of Nitre.

Hence, it is of a very different nature from Salt Armoniac.

Oyl of Vitriol and Nitre make fumes or steams, though no Effervescence.

[Page 57] Green Vitriol, with Spi­rit of Harts-horn, is scarce­ly moved. White Vitriol, with the same Spirit, ma­keth a conspicuous huff. And Roman Vitriol a ve­hement Effervescence.

Whence the former is the least acid, and the lat­ter the most of all. Which also confirms what I said before of the like natures of the several Metals to which they belong.

Salt of Vitriol, though a fixed Salt, and made by Calcination, yet maketh no [Page 58] Effervescence with the strongest acid; but only with Alkalies; as may be seen upon their mixture, but much better heard by holding the mixture to ones ear.

Hence, there are fixed Acids. Which further confirms what I have a­bove asserted concerning the nature of Gold, scil. That the predominant Salt thereof is a fixed Acid.

Sal Martis, with Spirit of Harts-horn, maketh a considerable huff.

[Page 59] Hence it is much more acid than green Vitriol; and is therefore a cooler body.

Alum and Sp. of Harts-horn make a plain Effer­vescence.

Saccharum Saturni with Oyl of Vitriol, stirs not at all. With Spirit of Salt, huffs a little. With Spirit of Nitre much more.

Hence the acid of the Vinegar, and not the Al­kaly of the Lead, is the predominant Principle.

Common Salt stirs nei­ther [Page 60] with Spirit of Salt, nor with Spirit of Nitre; nor with Aq. fortis▪ But with Oyl of Vitriol it ma­keth a great Effervescence with noise and steams.

Hence, even common Salt, though it be not reckoned amongst alka­lizate Salts, yet is far nearer in nature to that, than to an acid. Hence also the Spirit of Salt is a subalkalizate Acid, and of a very different nature from Oyl of Sulphur or Vi­triol.

[Page 61] Salt Armoniac, with spi­rit of Nitre, stirreth not. But with Oyl of Vitriol it maketh a great Efferve­scence.

Hence spirit of Nitre is a subalkalizate spirit.

Oyl of Vitriol and spirit of Nitre, though both acids, yet make a great smoak; greater than that which the spirit maketh of it self. Which confirms the last preceding Corollary.

Oyl of Vitriol and spirit of Salt, though both acids, yet make a strong Efferve­scence, [Page 62] with noise and fumes.

Which further con­firms, what was noted be­fore, scil. that Spirit of Salt is a subalkalizate A­cid.

Spirit of Salt Armonia [...] with Oyl of Vitriol, make an Effervescence so extra­ordinary quick, and as i [...] were instantaneous, tha [...] nothing seemeth quicker.

Whence it is probable That if Gun-powder wer [...] made of Salt Armoniac instead of Nitre, or with [Page 63] both mixed together; it would be far stronger, than any kind now in use. And thus far for Mine­rals.

I have only one Corol­lary to add, from the whole; which is, That whoever doth undertake the Natural History of a Country, (such as that the Learned Dr. Plot hath excellently performed of Oxford-shire) the fore­going Method, seemeth so easie, cheap, and indeceit­ful for the finding out [Page 64] and well distinguishing the natures of all kinds of Metals, Ores, Salts, Earths, Stones, or other subterra­neal bodies; as cannot, I think, be supply'd but by others of greater difficul­ty and expence.

CHAP. III.

I Now proceed to the several Parts of Ani­mals; as Hairs, Hoofs, Horns, Shells and shelly▪ [Page 65] Insects, Bones, Flesh and the several Viscera, Silk, Blood, Eggs, Musk, Ca­stor, Gall, Vrine, Dungs, Salts, and Stones.

And first of all, the Hair of a mans head, with Oyl of Vitriol, maketh no Bulli­tion at all. Nor yet with spirit of Nitre.

So that although it con­tains a good deal of vola­tile Salt; yet it seemeth either not to be alkali­zate, or else is centred in so great a quantity of Oyl, that the acid menstruum cannot reach it.

[Page 66] Hares Furr, with spiri [...] of Nitre, maketh, although a short, yet very plain Bul­lition and huff.

Hence the Hair, an [...] therefore the Blood, o [...] some Animals, is fuller o [...] Salt, at least of an alkali­zate Salt, than that o [...] some others. And perhap [...] the Hair of some men, a [...] of Blacks, may be so ful [...] of Salt, as to make a Bul­lition like Hares Furr.

The shavings of Nai [...] stir not at all, either wit [...] Oyl of Vitriol, or spirit o [...] [Page 67] Nitre: only with the latter they turn yellow.

Elks Claws, with spirit of Nitre, make a small and slow Bullition.

Horses Hoof, with Oyl of Vitriol, stirs not of ma­ny hours. But with spirit of Nitre, allowing it some time, makes a very plain Bullition, and huffs up ve­ry high.

Cows Horn, neither with Oyl of Vitriol, nor with spi­rit of Nitre, maketh any Bullition, only turneth to a yellow colour.

[Page 68] Rams Horn stirs no [...] with Oyl of Vitriol; bu [...] with spirit of Nitre, make [...] a small and slow Bullitio [...]

Harts-Horn makes [...] considerable Bullition a [...] huff, even with Oyl of Vi­triol, which the rest of th [...] Bodies above-said, will n [...] do. But with spirit of Ni­tre, it makes yet a greater.

From the foregoing Experiments, and almost all that follow, what wa [...] formerly asserted of the Salts of Vegetables and Minerals, is here also evi­dent [Page 69] concerning that of Animals, scil. That it is not made, but only sepa­rated by the fire.

It likewise hence ap­pears, That the proportion of Salt in the fore-men­tioned parts is very dif­ferent; and that there­fore some of them are ne­ver, and none of them but with good discretion, to be substituted one for another in Medicine.

As also, that there is a different proportion of Salt in the several Ani­mals [Page 70] themselves, to whic [...] the said Parts belong.

Next for shells; as thos [...] of Lobsters, Eggs, Snail [...] and Oysters: all whic [...] make an Effervescence both with Oyl of Vitriol and spirit of Nitre. Bu [...] with spirit of Nitre th [...] greatest.

Lobster-shells make a con­siderable Bullition and huff but no noise, nor steams.

Egg-shells make a Bul­lition and huff, with some noise, but no steams.

Snail-shells make an Ef­fervescence [Page 71] with noise and steams.

Oyster-shells make one with the greatest noise and thickest steams.

Hence we may judge, in what case to administer one more appositely than another. As also in what proportion, according to their different strength. Some may be better for Children, as being milder. Or for a Body whose ve­ry sharp Blood or other Humors, are very easily kindled into Ferments. [Page 72] Or else may be safest, to avoid a sudden precipita­tion of the Humors; or for some other cause.

Oyster-shells, and the rest above-said, make a quicker Effervescence, not only with spirit of Nitre, but even with spirit of Salt, tha [...] they do with Oyl of Sul­phur, or Oyl of Vitriol.

So that these Bodies, as well as Metals, have their proper Menstruums where­by they are best dissol­ved.

Egg-shells calcined, make [Page 73] with Oyl of Sulphur, or Oyl of Vitriol, or spirit of Nitre, a greater Efferve­scence, than when uncalci­ned. As also with steams; which uncalcined, they pro­duce not.

The like is seen in cal­cined Oyster-shells.

The longer the Calcina­tion is continued, the quick­er and stronger will be the Effervescence. This I try­ed at several terms, from a quarter of an hour, to five hours. So that after so long a Calcination, they [Page 74] make an Effervescence al­most instantaneous.

The reason hereof is, Because the Sulphur, be­ing for the greatest part driven away by the fire; the remaining Salt lies now more open and na­ked to the attaque of the Menstruum, so soon as e­ver they are mixed toge­ther.

From hence it is plain, That Egg-shells, and the others above-said, being burnt, are far stronger Me­dicines, than when un­burnt.

[Page 75] It is hereby likewise evident, That a great portion of their Salt, is not a volatile, but a fixed Alkaly.

To these may be sub­joyned all kinds of shelly Insects. I will instance in three or four.

And first Bees, with Oyl of Vitriol, stir not in the least. With spirit of Nitre they make an exceeding small Bullition, without any elevation.

Cochinele makes some Bullition with Oyl of Vi­triol, [Page 76] but very small: for the bubbles are not to be seen without a Glass. But with spirit of Nitre the Bullition is more visible, and joyned with some ele­vation.

Cantharides make no visible Bullition with Oyl of Vitriol. But with spirit of Nitre they do, and huff up rather more than Cochi­nele. Yet is this done very slowly, and comparatively with many other bodies, is not much.

Hence it is not the [Page 77] quantity, but the quality of their volatile Salt, which makes them so strong an Epispastick. For most of those bodies a­bove, and hereafter na­med, make a greater Bul­lition, and yet are neither Caustick nor Epispastick in the least.

It is hence also evi­dent, as hath been before suggested, That there are divers kinds of volatile Salts, eminently diffe­rent; some being high­ly alkalizate, others ve­ry [Page 78] little, and some scarce any thing so: such as those of Scurvygrass, A­nemone, Crowfoot, and ma­ny the like Plants; to whose Salts, this of Can­tharides seemeth to be very near of kin.

Millepedes make a Bul­lition and huff, much grea­ter and quicker, than any of the Insects above-na­med: and that both with spirit of Nitre, and Oyl of Virtriol it self. Yet is this Insect of a very temperate nature.

[Page 79] Whereby is further demonstrated, That the being simply alkalizate, is not enough to make a body to be Caustick.

Again, although Mille­pedes make a Bullition, greater than any of the In­sects above-named: yet is it much less, than that of Oyster, Snail, or even Egg-shells; and of divers o­ther bodies above, and hereafter mentioned.

Hence, being given to the same intent, as any of those bodies; it is the [Page 80] mildest and gentlest in its operation of them all.

Millepedes likewise cal­cined, make a stronger Ef­fervescence, than when un­calcined, as do Oyster-shells, &c.

So that it appears, That all Testaceous Salts, are, at least in part, fixed Salts.

I next proceed to Bones. And first Whale-bone ma­keth no Bullition at all with any acid.

A Cartilage, with spirit of Nitre, makes some very small bubbles, not to be [Page 81] seen without a Glass.

The Bone in the Throat of a Carp, makes a little and slow Bullition with spirit of Nitre.

The Spina of a Fish (that which I used was of a Cod-fish) maketh a Bul­lition one degree higher.

All sorts of Teeth, as of Dogs, Boars, the Sea-Horse, Elephant, make the like. As also the Bone of an Oxes heart.

So that all these are ve­ry gentle in their opera­tion, and fit for Children.

[Page 82] Sheeps and Calves Bones both of them make a Bulli­tion yet a little higher, e­specially with spirit of Ni­tre.

Cocks Bones somewhat higher than the former.

Cranium humanum a little higher than all the rest.

Bones likewise, being calcined, make a Bullition with Acids. And so doth also calcined Harts-horn. But in neither of them, is the Bullition advanced by Calcination, any thing com­parable [Page 83] to what it is in shells.

Whence it appears, That the Salt of Horns and Bones, is much more volatile, than that of Shells.

Next for Flesh and the several Viscera. And first, dryed and powdered Mut­ton, with Oyl of Vitriol, stirs not at all. But with spirit of Nitre makes a small Bullition and huff.

Sheeps Heart doth the like somewhat more appa­rently.

Vipers flesh produceth a [Page 84] froth, but huffs not.

Powdered Earth-worms make a great froth, and huff a little.

Powdered Tripe makes only a little Bullition.

Lamb-stones do the like.

Kidney, Spleen, and Li­ver, with some elevation.

Lungs, with bubbles very large; because extra­ordinary slowly.

Dryed Brain makes al­so a little and slow Bulli­tion.

Hence, there is a grea­ter proportion of Sulphur [Page 85] or Oyl, and less of an Al­kaly in all these parts, than there is in Bones, Shells, and divers other parts hereafter mentioned. And in some of them, as in the Brain, that Salt which there is, may rather be lodged in some sanguine­ous parts mixed with them, than in their own proper substance.

I proceed to instance in all sorts of Animal Con­tents.

And first, raw Silk, with spirit of Nitre, makes [Page 86] a very small Bullition, but the elevation is considera­ble.

The grumous part of the Blood dryed, with Oyl of Vitriol, stirs but little. But with spirit of Nitre it huffs up considerably.

Serum of Blood dryed, with the same spirit, makes a plain elevation, with a little Bullition.

Herewith may be recko­ned the White of an Egg, which is nothing but a pure Crystalline Serum separated from the common stock. [Page 87] This being dryed, with spi­rit of Nitre, huffs up rather more than even the gru­mous part of the Blood, the bubbles are much larger, break oftner, and the ele­vation sooner made.

Whence it seemeth, that there is a greater quantity of a volatile Al­kaly in proportion to the Sulphur, requisite to the Generation, than to the Nutrition of an Animal.

The Yolk of an Egg is scarce moved with spirit of Nitre, producing only a ve­ry [Page 88] few Bubbles. The Salt being either little alkali­zate, or else immersed in so great a quantity of Oyl, that the Menstruum can­not reach it.

For the same reason Sperma Ceti stirs not with any Acid. Neither doth Civet.

Russian Castor, with Oyl of Vitriol, stirs not. But with spirit of Nitre makes a considerable huff and froth. Yet it requires time.

Wherefore it seemeth, That Castor by virtue of [Page 89] its alkalizate Sulphur, be­comes so good a Corrector of the acido-alkalizate Sulphur of Opium: so I take leave to call it, ha­ving some reasons to be­lieve it such.

Musk, with Oyl of Vi­triol, stirs not. But with spirit of Nitre it makes a considerable and quick Bul­lition, with large bubbles, which often break and rise again.

Whence there is a ve­ry eminent difference be­twixt Musk and Civet.

[Page 90] Hence also, Musk is Cordial, not only from its Sulphur, but its Alka­ly; by both directly op­posite to preternatural Acidities.

Dryed Gall with spirit of Nitre for some time is still: but at length it makes a considerable Bul­lition and froth.

The reason why it is so long before it begins, is because the Salt, (as was observed of some o­ther Parts) is locked up in so great a quantity of [Page 91] Oyl. The abundance whereof is manifest, not only from Destillation, but also from hence, In that the dryed Powder, in ly­ing by, incorporateth all together into one body, as Mirrh, and some other softer and oily Gums are used to do.

Extract of Vrine, with spirit of Nitre, makes a Bullition with some Effer­vescence, which continues for a considerable time; and at last it huffs up with great bubbles. The Bulli­tion [Page 92] begins presently: the Salt being copious, and the Oyl but little.

The same Extract of Vrine makes a considera­ble bullition and froth, not only with spirit of Nitre, but even with Oyl of Vi­triol.

Hence the Salt of V­rine is more alkalizate than that in most of the afore-said Contents.

From this and some of the following Experi­ments, it also appears, That the Salt which con­curs [Page 93] to the generation or constitution of Gravel or of a Stone in the Kidneys or Bladder; is of a very different nature from the Salt of Vrine.

Next for Dungs. And first, dryed Goats-dung makes, with spirit of Ni­tre, a small bullition, but no elevation. That of Mice the like. And that of Cows. So that of all I have tryed, these three stir the least.

Goose-dung, with spirit of Nitre, makes a very small bullition and some [Page 94] elevation. But it requires time. Oyl of Vitriol stirs it not.

Album Graecum, with spirit of Nitre, besides in­numerable small bubbles, rises up with some great ones, exactly resembling the huffing up of Yest or Barm. Also with Oyl of Vitriol it maketh some lit­tle froth, but slowly.

So that it should seem, that the Bones are a little opened by some acid Men­struum in the Dogs sto­mach (as the body of Steel [Page 95] is in its preparation with Sulphur) whereby it be­comes a good mild Topick in Quinzies.

Hens dung, with spirit of Nitre, makes a very great bullition and huff: greater and quicker, than any of the rest above-na­med.

But of all I have tryed, Pigeons dung, with the same Spirit, maketh the greatest and the quickest Effervescence and huff; and that not without steams. Yet neither the same [Page 96] Dung, nor that of Hens, is moved in the least with Oyl of Vitriol.

The cause of so great an Effervescence in these, more than in the rest, is that white part which is here mixed in a great quantity with the Dung. Which white part, de­scendeth not from the Stomach, but is an Excre­ment separated from the Blood (as are Gall and the Succus Pancreaticus) by a peculiar Organ, which evacuates it into the Inte­stinum [Page 97] rectum; whence, together with the Stercus, it is excluded.

Hence it is evident, That in the said white part of Hen's, and espe­cially Pigeons dung, is con­tained a great quantity of a volatile Alkaly.

I proceed to Salts. And first Salt of Blood and V­rine both make a more du­rable Effervescence with Acids, than doth Salt of Wormwood, or Salt of Fern.

[Page 98] Hence the former are more alkalizate, than the latter.

Again, though divers other Animal Salts will not stir with Spirit of Salt, or with Oyl of Sulphur or Vitriol; yet the Salt of Blood will make an Effer­vescence with all kinds of Acids.

Whence it is further argued to be highly alka­lizate, and very proper for the correction of all sorts of preternatural A­cids [Page 99] in the body. There is little doubt, but that Spirit of Harts-horn will do the like.

The Tartar or Gravel which precipitates out of Vrine, with Oyl of Vitriol, makes no bullition in the least. Nor with strong spi­rit of Salt. But with spi­rit of Nitre, it makes a very great one, with Effer­vescence and steams.

From hence it appears, That there is much diffe­rence to be made in the [Page 100] use of acid Diureticks, Nephriticks, &c.

And that I may not altogether omit to men­tion, what may be so much for the good of mankind, I do here de­clare, That for prevent­ing the generation of the Stone, either in the Kid­neys, or in the Bladder, there are not better Me­dicines in the world, than some certain Preparations of Nitre, duly admini­stred. Who-ever shall [Page 101] think that any kind of acid, as Oyl of Sulphur, Oyl of Vitriol, Spirit of Salt, or the like, will have the same effects, will find themselves much decei­ved in their practice.

I conclude with Stones. And first, Spirit of Nitre dropped upon a Stone of the Kidneys or Bladder pro­duceth the very same ef­fect, as upon the Gravel in Vrine. That is to say, it makes it boil and huff up, until at length it is [Page 102] perfectly dissolved into a soft Pulp; which neither Oyl of Sulphur, nor Oyl of Vitriol, nor Spirit of Salt will do; nor give the least touch towards its dis­solution.

This confirms what I said before of the use of Nitre and Nitrous Spirits, if duly prepared and ad­ministred, above any o­ther Acids, against the Store.

Pearls, with any Acid, make the like Efferve­scence, [Page 103] as do Oyster-shells.

Magistery of Pearls, as usually prepared, stirs not at all, with any Alkaly or Acid.

So that as to the effect frequently intended by it, it is very insignificant; as of that of Corals hath been said.

Crabs Eyes, with any Acid, make an Efferve­scence, almost as quick as that of Oyster-shells.

Crabs Eyes likewise cal­cined, make a stronger Ef­fervescence, [Page 104] than when un­calcined.

So that these, as well as Shells, contain a fixed Alkaly.

The stones in Whitings heads make a strong Effer­vescence like that of Oy­ster-shells.

Stone of humane Gall, stirs not with Oyl of Vi­triol. But with spirit of Nitre maketh a little bul­lition just upon mixing, and after a considerable time, a little froth. Much less than [Page 105] what was observed before of the Gall it self.

So that it seemeth to be generated of the Gall coagulated by some Acid, which hath already refra­cted the Alkaly wherewith the Gall abounds.

This confirms the use of those Medicines in the Jaundies, or any other bordering Disease, which destroys those Acidities by which the Gall is curd­led or coagulated, and so rendred more difficultly [Page 106] separable into the Guts.

Bezoar, neither the We­stern, nor the Eastern, doth stir at all with Oyl of Vi­triol.

Western Bezoar, with spirit of Nitre, makes a very little thin froth, and that's all; and that it doth very slowly.

But Oriental Bezoar, with spirit of Nitre, after some time, maketh a very great Effervescence, with froth, elevation, noise, and steams▪ (as if you poured [Page 107] Oyl of Vitriol upon Salt of Tartar) till it be wholly dissolved by the affused Spirit, and turned into al­most a blood-red.

Hence it may seem to be no mean Remedy a­gainst such fretting and venenate Acids, as often­times in Feavers, and o­ther Distempers, lye a­bout the Stomach, and are thence frequently tran­slated to the Heart, Brain, Nerves, and other parts.

The difference like­wise [Page 108] betwixt the Western, and the Eastern Bezoar, is so great, that in any case of danger, and where the Bezoar is relyed up­on, it is an unpardonable fault, for the Apothecary, or any Person, to substi­tute the one for the other: unless he will take ten times as much, or ten times as little of the one, as he would have done of the other: if that will serve turn.

The Stones already [Page 109] mentioned, are ordinarily generated in the bodies of Animals. I have one instance more of some o­ther Stones which are ex­traordinary. In the City of Hereford lives a Maid, who often voids these stones, and in the space of some years last past, hath voided several pounds, of several co­lours, and sizes, not only per vias urinarias, but al­so by vomit, and by stool. The first mention made [Page 110] to me of them, was by Mr Digges, a worthy Gentleman of that City, as a thing that was there much wondred at. And some of them, upon my desire, were sent me by Mr. Wellington, a noted Apothecary in the same place. I have tryed what several acid Menstruums will work upon them; and find, That with Oyl of Vi­triol, and especially with spirit of Nitre the great ones make a very quick and [Page 111] conspicuous Effervescence. But the small ones, neither the white, nor the grey, make any bullition in the least: for in truth, they are no other but little Pebble and greet Stones.

This being considered, and the various colours and mixture of any one of the great Stones, being well observed; it seem­eth plain, That although she be somewhat old (a­bove thirty years) yet may she have a kind of [Page 112] [...], or diseased Appe­tite to Stones, Bones, Wood-ashes, Tabaco-pipes, Chalk, and such like things; which sometimes swal­lowing in little lumps, sometimes grosly, or fine­ly ground betwixt her teeth; they are in her Stomach and Bowels, more or fewer of them, cement­ed together, either with a pituitous, bilious, or some other more or less glutinous substance. And that by virtue also of the [Page 113] said Cement, or any of the said, or other like al­kalizate Bodies, the grea­ter Stones, which consist of those partly, do make an Effervescence with acid Liquors. Thus far of In­stances upon the parts of Animals. I shall close with some Corollaries de­duced from the whole.

And first, since we find, that amongst all the Menstruums we have made use of, Spirit of Ni­tre, or any very Nitrous [Page 114] Spirit, is the most univer­sal dissolver of all kinds of Animal bodies; the best dissolver of many o­thers both Vegetable and Mineral, and the only dis­solver of some: Hence it is probable, That the great stomachick Men­struum, which either dis­solves, or opens almost all Bodies which come into the Stomach, is a kind of Nitrous Spirit.

Again, Spirit of Nitre being a subalkalizate A­cid, [Page 115] and working more evidently upon Animal bodies, than other simpler Acids do, which yet are as strong; It hence fol­lows, That most of the Salts of Animals are sub­acid Alkalies. How far this conclusion may fur­ther instruct us, I shall have occasion to shew in another Discourse.

Lastly, there being so many, say twenty or thir­ty degrees, from the slow­est to the most vehement, [Page 116] in the Bullition of mixed Bodies; it seemeth, That Fermentation it self, as to the formal notion of it, is nothing else: or that from the common Lu­ctation of mixed Bodies whereof we have now bin speaking, it differs not in specie, but only in the manner of its causation, and in degree: the Aer, or some certain Men­struum lodged therein, being of no greater strength, than to produce [Page 117] a Bullition or Luctation of that low and soft de­gree, which we call Fer­mentation.

I have thus endeavou­red to prove, by various Instances, how instructive this most easie, plain and simple Method in the Mix­ture of bodies, may be­come to us: & that meer­ly by observing the Lucta­tions which thence arise betwixt them. How much more then, if a diligent remarque be made of all [Page 118] those various Colours, Smells, Tastes, Consisten­cies, and other Mutations thereupon emergent?

FINIS.
At a Meeting of the …

At a Meeting of the Council of the R. Society. January 21. 167 4/5.

Order'd,

THAT a Discourse made before the R. Society, Decemb. 10. 1674. by Dr. Ne­hemiah Grew, Concerning the Nature, Causes, and Power of Mixture, &c. be Printed by the Printer of the R. Society.

Brouncker. P. R. S.

A DISCOURSE Made before the ROYAL SOCIETY, Decemb. 10. 1674. Concerning the Nature, Causes, and Power of MIXTURE. By Nehemiah Grew, M. D. and Fellow of the R. Society.

LONDON, Printed for John Martyn Printer to the Royal Society, and are to be Sold at the Bell in St. Pauls Church-yard, 1675.

To the Right Honourable WILLIAM Lord Viscount BROVNCKER, PRESIDENT of the ROYAL SOCIETY.

My Lord,

ONE Reason why I dedi­cate the fol­lowing [Page] Discourse to Your Lordship, is because by Your great and undeserved re­spects, You have ob­liged me to do no less. How much more I cannot say, unless I were able to com­pute the value of Your obligation.

Another Reason, my Lord, is be­cause I could not [Page] but publickly return Your Lordship thanks, for minding the Roy­al Society of so good a way, as they are lately resolved upon, for the management of a great part of their business. Where­in, my Lord, I do more then presume, that I also speak the sense of the whole Society; I think, [Page] not any one except­ed.

I may with the same confidence inti­mate, my Lord, how happy they account themselves, in having a Person so fit to preside their Affairs, as Your Lordship▪ The largeness of Your Knowledge, the ex­actness of Your Judg­ment, the evenness [Page] of Your Comport; being some of those necessary Qualificati­ons, which His Ma­jesty had in His eye, (as right well un­derstanding what He did) when He fixed His choice upon Your Lordship.

I know, my Lord, that there are some men, who have just so much understand­ing, [Page] as only to teach them how to be am­bitious: the flatter­ing of whom, is some­what like the tick­ling of Children, till they fall a dancing. But I also know, that Your Lordship unconcerneth your self as much, in what I even now spake; as Caesar did himself, when his Souldiers [Page] began to style him King. For as he said, Non Rex, sed Caesar: so let Your Lordship be but once nam'd, and all that follows, is but a Tautology to what You are already known to be. Your being President of the Roy­al Society, Your be­ing the first that was chosen, and chosen [Page] by so Wise a King; amounteth to so high and real a Panegy­rick to Your Lord­ship, as maketh ver­bal ones to be su­perfluous, and leaves them without any sound.

Whence, my Lord, I have a third Rea­son most naturally e­mergent; which is, that I dare to sub­mit [Page] my self, as to what I have here­after said, to Your Lordships Censure. You being so able, and just an Arbiter, betwixt the same and all those persons there­in concern'd; that You can neither be deceived, nor corrupt­ed, to make a Judg­ment in any Point, to the injury of either.

[Page] And truly, my Lord, were it only from a principle of self-interest, yet I could not desire it should be otherwise. For the World, if it lives, will certainly grow as much wiser then it is; as it is now wiser then it was heretofore. So that we have as little reason, to de­spise [Page] Antiquity; as we can have willing­ness, that we our selves should be de­spised by Posterity.

Yet some difference there is to be made; viz. betwixt those of all Ages, who have been modestly igno­rant; and those who have thought, or pretended, that they were Omniscient. Or [Page] if knowing and ac­knowledging that they were ignorant; have yet not been content­ed to be so; un­less, with as good manners, as sense, they did conjure all Mankind, not to offer at the knowing any more then themselves.

Vpon the whole, my Lord, I desire not You should be [Page] a Patron, any fur­ther then You are a Judge. For if this small Essay hath deserved the least ac­ceptance, I am sure, that in being one, You will be both. Whereby, my Lord, You will not a lit­tle nourish and in­spire my future en­deavours of the like nature: being ve­ry [Page] sollicitous to ap­prove▪ my self,

My Lord,
Your Lordships most faithful and obedient Servant, Nehemiah Grew.

A DISCOURSE Made before the ROYAL SOCIETY.

HAVING the ho­nour to perform the task of this day; I shall endeavour to conform to the Philosophy, [Page 2] which this Society doth pro­fess; which is, Ratiocina­tion, grounded upon Experi­ment, and the Common No­tions of Sense. The former being, without the latter, too subtle and intangible; the latter, without the for­mer, too gross and unma­nageable: but both toge­ther, bearing a true ana­logy to our selves; who are neither Angels, nor meer Animals, but Men.

The Subject I have cho­sen [Page 3] to speak of, is Mixture. Whereof, that our Dis­course may be the more con­sistent, and the better intel­ligible; all I have to say, shall be ranged into this Method; viz.

1. First, I shall give a brief account of the receiv­ed Doctrine of Mixture.

2. Next, lay down some Propositions of the Principles whereof all Mixed Bodies consist.

3. Then, open the true [Page 4] Nature of Mixture; or say, What it is.

4. And then enumerate the Causes of Mixture; or say, How it is made.

5. Lastly, I shall shew the Power of Mixture; or, What it can do.

SECT. I.

FIRST, As to the re­ceived Doctrine of Mix­ture; not to trouble you with tedious quotations of [Page 5] what Aristotle, Galen, Fer­nelius, Scaliger, Sennertus, Riverius, and others say hereof; we may suppose the whole summed up in that Definition which Ari­stotle himself hath given of it, and which the greater number of his Followers, have almost religiously ad­hered to; viz. that 'tis, [...]. Lib. 1. de Gener. & Corrupt. Cap. ult. that 'tis, Miscibilium alterato­rum [Page 6] unio. Which Defini­tion, as it is usually expli­cated, is both Vnintelligi­ble, and Vnuseful.

Two things are unintel­ligible; what they mean by Alteration; and what by Vnion. In this Alteration, they say, That the very Forms of the Elements are alter'd. And therefore lay it down for an Axiom, Quòd in Mixto, Formae Elementa­res tantum sint in potentia. But let us see the conse­quence. [Page 7] For if in a mixed body, the Forms of the E­lements are but in potentia; then the Elements them­selves are but in potentia: for we all say, Forma dat esse. And if the Compound­ing Elements, are only in po­tentia; then the Compound; Body it self can be only in potentia: yet to say it is no more, is most absurd.

As for the Vnion of E­lements in a mixed Body; they make it such, as brings [Page 8] them at last to assert, the Penetration of bodies, and that the Vnion of mixed bo­dies is nothing else. For they say, it is made in such sort, that every particle of the mixed body, partaketh of the Nature of the whole. Which Nature, ariseth from the contemperated Quali­ties of the four Elements. Whence they conclude, That every particle of the mixed body, containeth in it self all the four Elements. [Page 9] Which is plainly to assert a penetration of bodies. For every Element is, at least, one particle; if therefore every particle of the mixed body, containeth four E­lements; then four parti­cles, are but one. I con­clude then, That the re­ceived Doctrine of Mixture, is Vnintelligible.

Whence it follows, That it is also Barren and Vnuse­ful. For who can make any use of that which he [Page 10] understandeth not? And the experience of so many years, wherein it hath been ventilated by the disputes of men, proveth as much: Scarce any of them, ex­cept the Learned Sennertus, daring to venture upon Ex­periment, for fear they should come to understand themselves.

It is confessed, that ma­ny gallant things have been found out by artificial Mix­ture. But no thanks to this [Page 11] Definition of it. For as an Ignorant Person may make bad Work, and a good Rule be never the worse; so an Ingenious Person may make good Work, and a bad Rule be never the better. The question is not, what have men done? but what have they done upon this foun­dation, Quòd Mixtio sit mis­cibilium alteratorum unio. Had this ever taught them to do any thing, even so much as to make the Ink [Page 12] wherewith they have wrote all their Disputes; I con­fess, they would have had something to shew for it. But the truth is, their no­tions of Mixture, have been so far from doing us any good, that they have done us much harm: being, through their seeming sub­tlety, but real absurdity, as so many phantastick Spectrums, serving only to affright men from coming near them, or the Subject whereof they treat.

[Page 13] I shall therefore endea­vour to open the true Na­ture of Mixture. And I shall build my Doctrine upon the Common Notions of Sense: which none can deny; and every one may conceive of. In order to which, I shall take leave to lay down some Propositions, of the Principles of all mixed bo­dies.

SECT. II.

1. AND first, by Prin­ciples, I mean Atomes, or certain sorts of Atomes, or of the simplest of Bodies. For otherwise they would not be Principles; for a compounded Principle, in strict speaking, is a contradiction. Even as fives, threes, or twos, are not the Principles of Number, but Vnites.

2. Whence, secondly, [Page 15] it follows, that they are also Indivisible. Not Mathe­matically; for the Atomes of every Principle have their dimensions. But Physically; and so, what is but one, cannot be made two.

If it be asked, Whether a Stick cut with a knife, be not of one, made two? I say, that a Stick, is not one body, but many milli­ons of bodies; that is, of Atomes; not any one where­of is divided within it self, [Page 16] but only they are separated each from other, where the Knife forceth its way. As in the drawing of a mans Finger through an heap of Corn; there is no division made in any one Grain, but only a separati­on of them one from ano­ther, all remaining still in themselves entire. I say therefore, that what is phy­sically one, is also most firm, and indivisible; that is, im­penetrable: for penetration is [Page 17] but the separation, not the division of Atomes.

3. Hence, thirdly, they are also Immutable. For that which cannot be divi­ded, cannot be chang'd. So that of the whole World of Atomes, not any one hath ever suffer'd, or can suffer the least mutation.

Hereupon is grounded the Constancy of Causes and Effects. So that, in all Ge­nerations, it is not less cer­tain, that the self same [Page 18] Principle is still propagated from the same; than, that Man is from Man. Where­fore, Compounded bodies are generated; but Princi­ples are not, but only pro­pagated; that is, in every Generation, they pass, in themselves unaltered, from one body, into another.

4. If Principles, or A­tomes are all Immutable; it again follows, That they are of divers kinds. For one and the same Principle, [Page 19] or kind of Atomes, will still make the same thing, and have the same effect: so that all Generations would then be the same. Where­fore, since they are Immu­table, they must be di­vers.

5. This diversity, for the same reason, is not small, but very numerous. For as the World, taken to­gether, is Natures Shop; so the Principles of Things, are her Tools, and her Ma­terials. [Page 20] Wherefore, as it speaks the goodness of a Shop; so the perfection of the Vniverse, That it is fur­nished with many Tools wherewith, and many Ma­terials whereupon to work. And consequently, that Philosophy beareth best its own name; which doth not strain all to two or three Principles, like two or three Bells in a Steeple, making a pittiful Chime: but try­eth to rise up to Natures [Page 21] own number, and so to ring all the changes in the world.

6. Yet doth not this vast Diversity, take away the Regiment and Subordina­tion, of Principles. There being a certain lesser num­ber of them, which either by their greater quantity, or other ways, have Rule and Dominion, in their se­veral Orders, over all the rest. For where-ever the Subject is Multitude, Order [Page 22] is part of its Perfection. For Order is Proportion. And how can Nature be imagin'd to hold Proporti­on in all things else, and not here? Wherefore, as certainly, as Order and Go­vernment are in all the parts of the Rational; so certain­ly, of the Material World.

Whence it is, That al­though the Species of Prin­ciples be very numerous; yet the Principles called Ga­lenical, Chymical, or any [Page 23] others, which do any way fall under the notice of Sense, are notwithstanding reduceable to a smaller num­ber: viz. according to the number of Predominant Prin­ciples in Nature; or, at least, in this part of the Vniverse which is near and round about us. To the Power and Empire whereof, all other Principles do sub­mit. Which Submission, is not the quitting of their own Nature; but only their [Page 24] appearance under the ex­ternal Face or Habit of the said Predominant Princi­ples.

7. As there can be no Order of Principles, without Diversity; so no Diversity, but what is originally made by these two ways; sc. by Size and Figure. By these they may be exceeding dif­ferent: and all other Pro­perties besides, whereby they differ, must be de­pendent upon these two.

[Page 25] 8. Nor therefore, can they be of any other Fi­gures, than what are Regu­lar. For Regularity, is a Similitude continu'd. Since therefore all kinds of A­tomes are divers only by their Size and Figure; if the self same Size and Fi­gure were not common to a certain number of Atomes, they could not be said to be of any one kind▪ and consequently, if there were no Similitude of Atomes, [Page 26] there could be no Distincti­on of Principles.

9. Hence also, these two Modes of Atomes, viz. their Size and Figure, are the true, and only original Qualities of Atomes. That is, an Atome is such or such, because it is of such a cer­tain Size and Figure.

10. Lastly, As these two Modes, taken several­ly, are the Qualities of an Atome: so consider'd to­gether, they are its Form. [Page 27] A substantial Form of a Bo­dy, being an unintelligible thing. I say of a Body; for although the Rational Soul be a substantial Form, yet is it the Form of a Man, and not of a Body. For the Form of a Body, we can conceive of no other­wise, then as of the Modi­fication of a Body, or a Com­plexion of all the Modes of a Body. Which also agrees with that Definition of a Form, which amongst the [Page 28] Peripatetick Philosophers is well enough accepted, viz. Quod sit, Ratio ejus Essentiae, quae cuique Rei competit. Which Ratio, if it be re­ferred to a Body, what is it but the Modification of that Body? Having thus proposed a Summary of my Thoughts about Princi­ples; I shall next proceed to shew what their Mixture is.

SECT. III.

AND first of all, from the Premisses, we ar­rive at this Conclusion; sc. That the Formation and Transformation of all Bodies, can be nothing else, but the Mixture of Bodies. For all Principles are immutable; as we have above proved: and therefore not genera­ble, formable, or transfor­mable. And the Forms of [Page 30] Principles, being but their Modes, are also immutable. So that the whole Business of the Material World, is nothing else, but Mix­ture.

Again, as Nature wor­keth every where only by Mixture; so is this Mixture every where but one thing, and can be but one. For whether it be the Mixture of great Bodies, or of small; of Compounds, or of Atomes; it is every where Mixture, [Page 31] and the Mixture of Bodies. Wherefore, Mixture is ei­ther an intelligible Affection of all Bodies, or of none; which latter, no man will say. As many wayes, therefore, as we can see, or conceive the Mixture of any gross Bodies, which we hold in our hand; so ma­ny ways, we may, of the subtilest Mixtures which Na­ture maketh, or of Atomes themselves; and no other wayes.

[Page 32] Now all the wayes we can distinguish Mixture by, are in general these two; either in respect of the Bo­dies Mixed, or else of the Modes of the Mixture it self.

In respect of the Bodies Mixed, Mixture is distin­guished also two ways; viz. by Conjugation, and by Pro­portion.

By Conjugation, I mean, a Certain Mixture of some such Principles, and not of [Page 33] others. Which is three­fold.

First, As to Number: as when one Body may be compounded of two Prin­ciples, another of three, a third of four, a fourth of five, and so on.

Secondly, As to Kind: where, though there be a conjunction of the same Number, yet not of the same Kind.

Thirdly, When they dif­fer from one another both [Page 34] in Number and Kind.

So many ways the Prin­ciples of Bodies may be conceived to be Conjugated; and therefore are: for here, that which may be, is. The Consequence is clear. For first, Nature hath various Materials wherewith to make these Mixtures; as we have shew'd. Secondly, By these Mixtures she may, and without the concurrence of any imaginary Forms, [Page 35] must produce all the varie­ties in the material world; as likewise hath been said. Wherefore, since all ima­ginable Mixtures may be made, and that to some pur­pose; if they should not be so, Nature would be Imper­fect: because we our selves can think, how she might put her Materials to further use, then so she would do.

To think, therefore, that all kinds of Principles, [Page 36] or all Elements go to make up every Compounded Body; is a conceit, no more to be credited, then one that should tell us, all kind of Wheels and other parts of a Watch, were put into a Clock; or that there were no other Materials where­with to build an House, then for a Tent or a Ship. For why should Nature, the great Artificer by which all perfect Works are made, be feigned to cram and [Page 37] ram all things into one, which we our selves look upon as absurd?

Secondly, The Mixture of Principles is diversifi'd, as by Conjugation, so also by Proportion. That is, by the divers Quantities, of the several Principles or Parts mixed together.

As if the quantity of one, were as five to ten; of a second, as five to fif­teen; of a third, as five to twenty, &c.

[Page 38] Or if that of one, be as five to six; of a second, as six to seven; of a third, as seven to eight. By which, and by other Proportions, Mixture may be varied in­numerable ways.

Again, As Mixture is varied with respect to the Bodies Mixed; so likewise in respect of the Mixture it self, which I call the Loca­tion of Principles, or the Modes of their Conjunction. Which may be various, [Page 39] as well as their Conjugation and Proportion. Yet are they all reduceable unto two general Modes: all Bodies, and therefore all Principles, being Mixed, either by Mediation, or by Contact.

Now all Contact, whe­ther of Compounds, or of Atomes, can be no other way, then such as is an­swerable to their Figures. Whereof, therefore, we can conceive but three ge­neral ways, viz.

[Page 40] First, By Contact in a Point, or some smaller part: as when two Atomes meet, which are globular or other­wise gibbose.

Secondly, By Contact in a Plain: as in the conjun­ction of the sides of Trian­gular or Quadrangular A­tomes, or otherwise flat.

Thirdly, By Contact in a Concave: as when one A­tome is admitted into the Concave or hole of another; as a Spigot is into a Fos­set.

[Page 41] The first may be called, Apposition; the second, Ap­plication; the third, Re­ception or Intrusion.

In the two last wayes, Atomes may be joyned by Mediation; but best of all the last. As when the two extreams of one Atome are received into the Con­caves or the holes of two others.

And these are all the general ways, whereby we can conceive Bodies to be [Page 42] Mixed together; sc. by their various Conjugation, Pro­portion, and Location.

So that the Composition of Atomes, in Bodies; is like that of Letters, in Words. What a Thunder­clap would such a Word be, as wherein all the four and twenty Letters were pack'd up? One therefore is com­pounded of more, another of fewer; this of some, and that of others: and both the Conjugation, Pro­portion, [Page 43] and Location of Letters is varied in every Word: whereby, we have many thousands of differing Words, without any altera­tion at all, in the Letters themselves; and might have ten times as many more. In like manner, therefore, or in the self same analo­gous way, as the Letters of the Alphabet, are the Principles of Words; so Prin­ciples, are the Alphabet of Things.

[Page 44] What we have said of Principles; and of Mixture as consequent thereupon; may be a foundation for an intelligible account, of the Nature and Cause of most of the Intrinsick Properties, and Qualities of Bodies: as of Gravity, Levity, Fixity, Fluidity, Angularity, Round­ness, Heat, Cold, Blackness, Whiteness, Sowerness, Sweet­ness, Fragrancy, Fetidness, and very many more. I say an intelligible account; [Page 45] sc. such as is grounded up­on the Notions of Sense, and made out Mechanically. But the exemplification hereof, being too large a field for this, or any one Lecture, I shall, before I come to the Causes of Mixture, only deduce from the Premisses, these following Corolla­ries.

1. First, That there is no alteration of Principles or of Elements, in the most perfect Mixture of Bodies. [Page 46] It cannot be; for Principles are Immutable, as we have said. And if it could be, yet it needeth not to be: for they are also many, and compoundable infinite ways; as hath been shewed. So that we have no need to perplex our selves with any of those difficulties, that arise from the Doctrine of the Alteration of Elements. The ground of which con­ceit, is that, of there be­ing but four Elements, and [Page 47] that all the Elements must needs be in every Body. And so men being puzled, how from thence to make out the infinite variety of Bodies, they feigned them to be alterable, and alter'd, upon every perfect Mixture. Not considering, that if their four Elements be alte­rable; as few as they are, no fewer then three of them may be spared: for one Element, if alterable, may be made any.

[Page 48] 2. Hence, secondly, may be solved that great Dispute, Whether such as we call Lixivial Salts, are made by the fire?

For first, No Principle is made by the fire: all Principles being unalterable; and therefore unmakea­ble.

Secondly, We must there­fore distinguish betwixt the Principle, and the Mo­dification of a Principle; or its various Mixture with [Page 49] other Principles, whence it may receive a various deno­mination.

Wherefore, a Lixivial Salt, qua Lixivial, is certainly made by the fire. But quate­nus Salt, it is not: that Prin­ciple being extractable out of most Bodies; and by divers other ways, then by the fire. For whether you Calcine a body, or Ferment it, (after the manner shew'd by the diligent and curious Improver of Chymical Knowledg, Dr. [Page 50] Daniel Coxe) or else putrifie it under ground, or drown it in the Sea; it still yield­eth some kind of Salt. All which Salts are made, not by making the Saline Principle; but only by its being vari­ously Mixed, upon those va­rious ways of the Solution of Bodies, with other Princi­ples: from which its various Mixture, it receives the vari­ous Denominations, of Marine, Nitrous, Volatile, or Lixivial.

3. Hence, thirdly, the most [Page 51] perfect Mixture of Bodies, can go no higher then Con­tact. For all Principles are unalterable; and all Matter is impenetrable; as hath been said. In the most visible and laxe Mixture, there is Con­tact; and in the most subtile and perfect, as in Generation it self, there is nothing more.

4. Hence, fourthly, we ea­sily understand, how divers of the same Principles, be­longing both to Vegetables and many other Bodies, are [Page 52] also actually existent in the Body of Man. Because even in Generation, or Transmuta­tion, the Principles which are translated from one body to another, as from a Vegetable to an Animal, are not in the least alter'd in themselves; but only their Mixture, that is, their Conjugation, Proporti­on, and Location, is varied.

5. Hence also the diffe­rence of Mixture, arising from the difference of Con­tact, is intelligible; sc. as to [Page 53] those three degrees, Congrega­tion, Vnion, and Concentration.

Congregation, and Inconsi­stent Mixture, is when the se­veral Atomes touch but in a Point, or smaller part▪ In which manner, I have divers arguments, inducing me to believe the Atomes of all Fluid Bodies, qua Fluid, do touch; and in no other.

Vnion, is when they touch in a Plain. As in the Crystals and Shootings of all Salts, and other like Bodies. For if [Page 54] we pursue their divided, and subdivided parts, with our eye, as far as we can; they still terminate, on every side, in Plains. Wherefore, 'tis intelligible, That their very Atomes do also termi­nate, and therefore touch, in Plain.

Concentration, is when two, or more Atomes touch by Reception and Intrusion of one into another: which is the closest, and firmest Mix­ture of all; as in any fixed, [Page 55] unodorable, or untastable bo­dy: the Atomes of such bo­dies, being not able to make any Smell or Tast, unless they were first dissolved; that is to say, unpin'd one from another.

6. Hence, sixthly, we under­stand, how in some cases, there seemeth to be a Pene­tration of Bodies; and in what sense it may be admitted: viz. if we will mean no more by Penetration, but Intrusion. For the Intrusion of one A­tome [Page 56] into the Concave or hole of another, is a kind of Pe­netration; whereby they take up less room in the mixed Body, then they would do by any other way of Con­tact. As a naked knife and its sheath, take up almost double room, to what they do, when the knife is sheathed.

Whence we may assign the reason, Why many Liquors being mixed; take up less room or space, then they did [Page 57] apart; as they very Ingenious M. Hook maketh it to appear by Experiment that they do. I say the plain reason hereof, or at least one reason, is the Intrusion of many of their A­tomes one into another. Which yet is not a Penetra­tion of Bodies strictly so called.

7. If all that Nature ma­keth, be but Mixture; and all this Mixture be but Contact: 'tis then evident, That Na­tural and Artificial Mixture, [Page 58] are the same. And all those seeming subtilties whereby Philosophers have gone about to distinguish them; have been but so many Scar­crows, to affright Men from the Imitation of Nature.

8. Lastly, Hence it fol­lows, That Art it self may go far in doing what Na­ture doth. And who can say, how far? For we have no­thing to Make; but only to Mix those Materials, which are already made to our [Page 59] hands. Even Nature her self, as hath been said, Maketh nothing new; but only Mix­eth all things. So far, there­fore, as we can govern Mix­ture, we may do what Na­ture doth.

Which, that we may still the better understand; let us before, and in the next place, see the Causes of Mix­ture. For since Natural and Artificial Mixture are the same; the immediate Causes of both, are and must be the same.

SECT. IV.

NOW all the Causes of Mixture we can conceive of, must, I think, be reduced to these six in ge­neral; viz Congruity, Weight, Compression, Solution, Digesti­on, and Agitation.

1. Congruity, or aptitude and respondence betwixt the Sizes and Figures of parts to be mixed: whereby bodies may be truly called the In­strumental Causes of their [Page 61] own Mixture. As when a plain answers to a plain, a square to a square, a convex to a concave, or a less to a greater or an equal, &c. ac­cording to which Respon­dencies in the parts of Bo­dies, they are more or less easily mingleable.

2. Weight; by means where­of, all Fluid Bodies, upon supposition of the Congrui­ty of their parts, must un­avoidably mingle

3. Compression; which either [Page 62] by the Air, or any other bo­dy, added to Weight, must, in some degree, further Mix­ture. Because, that Weight it self is but Pression.

For further proof of all the said Causes, I made this Experiment▪ Let Oyl of Anise­seeds, and Oyl of Vitriol be put apart into the Receiver of an Air-Pump. And, having ex­hausted it of the Air, let the two said Oyls be then affused one upon the other. Where­upon

[Page 63] First, It is visible, that they here mix and coagulate to­gether; that is, their parts are wedged and intruded one into another, without the usual compression of the Air; for that is exhausted: and therefore only, by the Con­gruity of their receiving and intruding parts; and by their Weight; by which alone they are so compressed, as to make that Intrusion.

Secondly, It is also evident, That although they do Co­agulate; [Page 64] yet not altogether so much, as when powred together in the same man­ner, and quantity, in the o­pen Air. Wherefore, Compres­sion, whether made by the Air, or any thing else, doth somewhat further the Mix­ture of Bodies, and the great­er the Compression, the more.

4. Solution; For all bodies mix best, in Forma fluida. And that for two reasons.

First, Because the parts of a body are not then in a [Page 65] state of Vnion, but of Separa­tion; and therefore, in a more capable state, for their Mix­ture and Vnion with the parts of another body.

Secondly, Because then they are also in a state of Motion, more or less; and therefore, in a continual tendency to­wards Mixture; all Mixture being made by Motion.

Wherefore, all Generations, and most perfect Mixtures in Nature, are made by Fluids; whether Animal, Vegetable, or [Page 66] Mineral. Which is also a­greeable to the Doctrine of the Honourable Mr. Boyle, in his excellent Treatise of the Nature and Vertues of Gems.

And 'tis well known, That bodies are ordinarily petri­fied, or Stones made, out of Water. That is, out of petrify­ing parts dissolved per mini­ma in Water, as both their Menstruum and their Vehicle. Wherefore, if we will talk of making Gold; It must not be by the Philosophers Stone, [Page 67] but by the Philosophers Liquor.

5. Digestion. For which there is the same reason, as for Mixture, by Solution. For

First, All heat doth attenu­ate, that is, still further sepa­rate the parts of a body; and so render them more min­gleable with the parts of a­nother. And therefore

Secondly, Doth also add more Motion to them, in or­der to their Mixture.

6. Agitation. Which I am [Page 68] induced to believe a great and effectual means of Mix­ture, upon divers considera­tions. As

First, That the making of Blood in the Bodies of Ani­mals, and the mixing of the Chyle therewith, is very much promoted by the same means; sc. by the Agitation of the parts of the Blood and Chyle, in their continual Circulation.

Again, From the making of Butter out of Milk, by the [Page 69] same means; whereby alone is made a separation of the oleous parts from the whey, and a mixture of them toge­ther.

Moreover, From the great Effects of Digestion; well known to all that are con­versant in Chymical Prepara­tions. Which Digestion it self, is but a kind of insensible A­gitation of the parts of di­gested bodies.

'Tis also a known Experi­ment, That the readiest way [Page 70] to dissolve Sugar in Wine or other Liquor; is to give the Vessel a hasty turn, together with a smart knock, against any hard and steady body: whereby all the parts of the Sugar and Liquor, are put into a vehement Agitation, and so immediately mixed together.

And I remember, that ha­ving (with intent to make Mr. Mathews's Pill) put some Oyl of Turpentine and Salt of Tartar together in a bottle, [Page 71] and sent it up hither out of the Country; I found, that the continual Agitation upon the Road, for three or four days, had done more to­wards their Mixture; then a far greater time of Digestion alone had done before. And it is certain, That a vehe­ment Agitation, especially if continu'd, or joyned with Digestion; will accelerate the Mixture of some bodies, ten times more, then any bare Digestion alone; as may be [Page 72] proved by many Experi­ments.

I will instance in this one. Let some Oyl of Turpentine and good Spirit of Nitre be stop'd up together in a bot­tle, and the bottle held to the fire, till the Liquors be a little heated, and begin to bubble. Then having remo­ved it, and the Bubbles by degrees increasing more and more; the two Liquors will of themselves, at last fall into so impetuous an [Page 73] Ebullition, as to make a kind of explosion; sending forth a smoak for the space of almost two yards high. Whereupon, the parts of both the Liquors, being violently agitated, they are, in a great portion, incorpo­rated into a thick Balsam in a moment: and that without any intense heat, as may be felt by the bottle. And thus much for the Causes of Mix­ture.

SECT. V.

HAVING enumerated the general Causes, we [Page 74] shall, lastly, enquire into the Power and Vse of Mixture; or, into what it can Do and Teach. And I shall Instance in fix particulars.

First, To Render all Bodies Sociable, whatsoever they be.

Secondly, To Make Artificial Bodies in Imitation of those of Natures own production.

Thirdly, To Make or Imitate the sensible Qualities of Bo­d [...]es; as Smells, and Tasts▪

Fourthly, To Make or Imi­tate their Faculties.

[Page 75] Fifthly, It is a Key, to disco­ver the Nature of Bodies.

Sixthly, To discover their Use, and the Manner of their Medicinal Operation.

Instance I.

FIRST, To render all Bo­dies Sociable or Mingle­able: as Water with Oyl, Salt with Spirit, and the like. For Natural and Artificial Mix­ture, are the same; as we have before proved. If therefore Nature can do it, as we see in the Generation of bodies she [Page 76] doth; 'tis likewise in the Power of Art to do it.

And for the doing of it, two general Rules result from the Premisses, sc. The Applica­tion of Causes, and the Choice of Materials. As for the Cau­ses, they are such as I have now instanc'd in. And for the Application of them, I shall give these two Rules.

First, That we tread in Na­tures steps as near as we can; not only in the application of such a Cause, as may be most [Page 77] proper for such a Mixture; but also in allowing it suffi­cient time for its effect. For so we see Nature her self, for her more perfect Mixtures, usually doth. She maketh not a Flow­er, or an Apple, a Horse, or a Man, as it were in a moment; but all things by degrees; and for her more perfect and ela­borate Mixtures, for the most part, she requireth more time. Because all such Mixtures are made and carri'd on per mi­nima; and therefore require [Page 78] a greater time for the com­pleating of them.

A second Rule is, Not only to make a due Application of the Causes; but sometimes to Accumulate them. By which means, we may not only I­mitate Nature, but in some cases go beyond her. For as by adding a Graft or Bud to the Stock, we may produce Fruit sooner, and sometimes better, then Nature by the Stock alone would do: So here, by accumulating the [Page 79] Causes of Mixture; that is, by joyning three, or four, or more together; or by applying more in some cases, where Nature applyeth fewer; we may be able to make, if not a more perfect, yet a far more speedy Mixture, than Nature doth. As by joyning Compression, Heat, and violent Agitation, and so continuing them all together, by some means contrived for the purpose, for the space of a week, or moneth, or longer, without [Page 80] cessation. Which may pro­bably produce, not only strange, but useful effects, in the Solution of some, and the Mixture of other Bodies. And may serve to mix such Bodies, as through the small number of their congruous parts, are hardly mingleable any other way. Agitation be­ing, as carrying the key to and fro, till it hit the lock; or within the lock, till it hit the wards.

Secondly, For the Choice of [Page 81] Materials, if they are not im­mediately, that is, of them­selves, mingleable; we are then to turn one species of Mix­ture into a Rule; which is, To mix them by mediation of some third, whether more simple or compounded body, which may be congruous in part to them both: as sul­phurious Salts are to Water and Oyl; and are for that rea­son mingleable with either of them.

Or, By any two congruous [Page 82] Bodies, which are also, in part, congruous to two others: and other like ways. Where­by the parts of Bodies, though never so heterogeneous, may yet be all bound and lock'd up together. Even as twenty keys may be united, only by uniting the two Rings where­on they hang.

The consideration of these things, have put me upon making several Experiments, for the Mingling of heteroge­neous Bodies. I shall give two [Page 83] Examples of tryal; the one upon fluid, the other upon consistent, Bodies.

For the first, I took Oyl of Anise-seeds, and powring it upon another Body; I so or­der'd it, that it was thereby turned into a perfect milk-white Balsam, or Butter. By which means the said Oyl be­came mingleable with any o­ther Liquor, Oyl, Wine, or Wa­ter; easily, and instantaneously dissolving therein, in the form of a Milk▪ And note, That this [Page 84] is done, without the least al­teration of the smell, tast, na­ture or operation of the said Oyl.

By somewhat the like means, not only Oyl of Anise-seeds, but any other stillatiti­ous Oyl, may be transformed into a perfect milk white But­ter; and in like manner be mingled with Water or any o­ther Liquor. Which is of va­rious use in Medicine; and what I find oftentimes very con­venient and advantageous to be done.

[Page 85] Again, Not only fluid but consistent bodies, which of themselvs will mix only with Oyl; by due mixture with o­ther bodies, may be render'd easily dissoluble in Water; as may Rosin, and all resinous and friable Gums. As also Wax: and this without chan­ging much of their Colour, Tast or Smell. Whereof like­wise, whatsoever others may do, the Physician may make a manifold Vse.

Instance II.

BY Mixture also, we may be taught to Imitate the Productions of Nature. As to which, from what we have before said of Mixture, we may conclude; That there is no generation of Bodies un­organical, but what is in the power of Mixture to imitate. As of Animals, to Imitate Blood, Fat, Chyle, Spittle, Flegm, Bile, &c. Of Vegetables, to Imitate a Milk, Mucilage, Rosin, Gum, or Salt. Of Mine­rals, [Page 87] to Imitate Vitriol, Allom, and other Salts; as also Me­tals, and the like.

I do not say, I can do all this: but if upon good pre­misses we may conclude this may be done; it is one step to the doing of it. But I will also give an Instance of somewhat that may be done in every kind. And

1. First, For the Imitation of an animal body, I will in­stance in Fat. Which may be made thus; Take Oyl O­live, [Page 88] and powr it upon high Spirit of Nitre. Then digest them for some days. By de­grees, the Oyl becomes of the colour of Marrow; and at last, is congealed, or hardned into a white Fat or Butter, which dissolveth only by the fire, as that of Animals.

In converting Oyl thus in­to Fat, it is to be noted, That it hardens most upon the ex­halation of some of the more Sulphureous parts of the Spi­rit of Nitre. Which I effected, [Page 89] well enough for my pur­pose, by unstopping the glass after some time of di­gestion; and so suffering the Oyl to dissolve and thicken di­vers times by successive heat and cold.

Hence, The true Congealing Principle, is a Spirit of Nitre separated from its Sulphur. For the better doing whereof, the Air is a most commodi­ous Menstruum to the said Spirit of Nitre.

Whence also, if we could [Page 90] procure such a Spirit of Ni­tre, we might congele Water in the midst of Summer. We might also refrigerate Rooms herewith artificially. And might Imitate all frosty Mete­ors. For the making of Fat, is but the Durable Congelation of Oyl▪ which may be done without frost, as I have shew'd how.

Hence also it appears, That Animal Fat it self, is but the Curdling of the Oily parts of the Blood; either by some of [Page 91] its own Saline parts; or by the Nitrous parts of the Air mingled therewith.

Hence likewise it is, That some Animals, as Conies, and Fieldfares, grow fatter in fro­sty weather: the oily parts of the blood, being then more than ordinarily coagulated with a greater abundance of nitrous parts received from the Air into their bodies.

For the same reason it is, That the Fat of Land-Ani­mals is hard; whereas that of [Page 92] Fish is very soft, and in a great part runs to Oyl, sc. Because the Water, wherein they live, and which they have instead of breath, hath but very few nitrous parts in it, in comparison of what the Air hath.

2. For the Imitation of a Ve­getable Body, I will give three Instances; In Rosin, Gum, and a Lixivial Salt. The first may be made thus; Take good Oyl of Vitriol, and drop it upon Oyl of Anise-seeds; and they [Page 93] will forthwith incorporate to­gether; and by degrees, will harden into a perfect Rosin; with the general and defining Properties of a truly Natural Resinous Gum. Being not in the least dissoluble in Water; or at least, not any more, then any natural Rosin or Gum: yet very easily by fire: as also highly inflammable: and exceeding friable.

Although this artificial rosin, be the result of two Liquors, both which very strongly [Page 94] affect the Sense: yet being well washed from the unincorpora­ted parts, (which is to be done with some care) it hath scarce any Tast or Smell.

The Concentration of these two Liquors, is likewise so u­niversal; that the Rosin is not made by Precipitation, but al­most a total Combination of the said Liquors; and that with scarce so much, as any visible fumes.

Again, Having taken a cer­tain Powder and a Saline Li­quor, [Page 95] and mixed them toge­ther in a bottle, and so dige­sted them for some time; the Powder was at last transmu­ted to a perfect Oily Gum; which will also dissolve ei­ther in Oyl, or in Water; in the self same manner, as Galba­num, Ammoniac, and the like will do.

And Lastly, A Lixivial Salt may be imitated thus; Take Nitre, Oyl of Vitriol, and high Spirit of Wine, of each a like quantity. Of these three Bo­dies, [Page 96] not any two being put together; that is to say, nei­ther the Nitre with the Oyl, nor the Oyl with the Spirit, nor the Nitre with the Spi­rit; will make the least ebul­lition: yet all three mingled together, make a very conspi­cuous one. The Spirit of Wine being as the Sulphur; and so that, and the Nitre together, standing, as it were, in the stead of an Alkalizate, that is, a Sulphurious Salt, against the Oyl of Vitriol. Divers [Page 97] other Experiments I can shew of the like nature.

3. In the last place, for the Imitation of a Mineral Body, I will instance in two, sc. Ni­tre and Marine Salt; if I may have leave to reckon them amongst Mineral Bodies. As for Nitre, by mixing of four Liquors together, and then setting them to shoot; I have obtained Crystals of true and perfect Salt; which have had much of a nitrous tast; and would be melted with a gen­tle [Page 98] heat, as Nitre is; and even as easily as Butter it self: I mean, not by the addition of any sort of Liquor, or any other body, to dissolve it; but only by the fire.

And as for a Sea-Salt, that I might Imitate Nature for the making hereof, I consi­der'd, That the Salt so cal­led, was nothing else but A­nimal and Vegetable Salt, freed from its true Spirit and Sulphur, and some Sa­line particles, specifically Ani­mal [Page 99] or Vegetable, together with them. For both Animal and Vegetable bodies being continually carried by all Rivers into the Sea; and ma­ny likewise by Shipwrack, and divers other ways, im­mersed therein: they are at last corrupted, that is, their Compounding parts are open­ed and resolved. Yet the Re­solution being in the Water, is not made precipitately, as it is in the Air; but by de­grees, and very gently. [Page 100] Whence the Sulphurious, and other more Volatile parts, in their avolation, make not so much hast, as to carry the more fixed Sa­line parts along with them; but leaveth them behind in the Water, which imbibeth them, as their proper Men­struum.

And the Imitation of Na­ture herein, may be per­formed thus; Put as much of a Lixivial Salt as you please, into a wide mouth'd [Page 101] bottle, and with fair Water make a strong Solution of it; so as some part thereof may remain unresolved at the bottom of the bottle. Let the bottle stand thus for the space of about half or three quarters of a year, all the time unstopped. In which time, many of the Sulphurious and other more Volatile parts gradually fly­ing away; the top of the un­resolved Salt will be incru­state, or as it were frosted [Page 102] over, with many small and hard Concretions, which for their nature, are become a true Sea-Salt. Whereof there is a double proof; First, In that most of the said Concretions are of a Cu­bical, or very like Figure. Especially on their upper parts; because having a fix­ed body for their basis, their under parts, therefore, con­tiguous thereto, are less re­gular. Whereas the parts of Salt in the Sea, being envi­roned [Page 103] on all sides with a fluid; their Figure is there­fore on all sides regular. Secondly, In that a strong Acid Spirit or Oyl being powred upon a full body'd Solution hereof; yet it ma­keth herewith no Ebulliti­on; which is also the property of Sea-Salt. And thus much for the more general Imita­tion of Bodies.

Instance III.

FROM the aforesaid Premisses, and by the aforesaid Means, there is no doubt to be made, but that also the other sensible Quali­ties of Bodies may be Imita­ted, as their Odours and Tasts. And that not only the ge­neral ones, as Fragrant, or Astringent: but also those which are specifical and pro­per to such a species of Bo­dies. [Page 105] Thus, for example, by mixing several Bodies toge­ther, in a due proportion, I have Imitated the Smells of divers Vegetables; as of Tansy, of Lignum Rhodium, and others. And I conclude it feasable, To Imitate the Tast or Smell of Musk, or Amber­greece, or any other body in the world.

Instance IV.

HENCE also we may be Taught, How to I­mitate the Faculties, as well as other Qualities of Bodies. The reason is, because even these have no dependance upon any substantial Form; as in the first Part of my last Book of the Anatomy of Vegetables, I think, I have, in a few lines, clearly made out: but are the meer re­sult [Page 107] of Mixture; effected by the same Causes, whether in Nature or Art; as also in the premisses of this Discourse hath been shew'd.

Instance V.

FROM whence, again, it is likewise a Key to Discover the Nature of Bo­dies. For how far soever we can attain to Mingle, or to Make them, we may also know what they are.

[Page 108] For Bodies are mingleable, either of themselves, or by some third. As to those which mingle of themselves, we may certainly conclude, That there is a congruity be­twixt them, in some respect or other. So upon various tryals I find, that Essential Oyls do more easily imbibe an Acid, then an Alkaly. Whence it is evident, That there is some congruity and similitude betwixt Essential Oyls, and an Acid, which [Page 109] there is not betwixt the said Oyls and an Alkaly.

As to those that mingle only by some third; we may also certainly conclude, That though the two ex­treams are unlike; yet that they have both of them a similitude to or congruity with that third, by which they are united.

Moreover, We may make a Judgment from the Manner or Degree of Mixture. Thus the Acid Spirit of Nitre, as is [Page 110] said, will coagulate Oyl-Olive, and render it consistent. Whence it might be thought, That any other strong Acid will do the like; and that therefore, there is no great difference in the Nature of the said Acid Li­quors. But the contrary hereunto, is proved by Ex­periment. For having digested the same Oyl, in the same manner, and for a much longer time, with strong Oyl of Sulphur; although it [Page 111] thence acquired some change of Colour, yet not any Consistence.

Again, Because the said Spirit of Nitre coagulates Oyl-Olive; it might be ex­pected, it should have the same effect, upon Oyl of A­nise-seeds; or, at least, that if other Acids will coagulate Oyl of Anise-seeds, that this should do it best. But Ex­periment proveth the con­trary. For of all I have try­ed, Oyl of Vitriol is the only [Page 112] Acid that doth it instan­taneously. Oyl of Sulphur, if very strong, will do it; but not so soon, nor so much. Aqua fortis, and Spirit of Salt, for the present, do not at all touch it. And Spirit of Nitre it self will not coagulate it, under eight or ten hours at least.

Instance VI.

LASTLY, and con­sequently, It is a Key, To Discover the Me­dicinal Vse and Operati­on of Bodies. Thus, for example, by the I­mitation of Rosins and Resinous Gums, we cer­tainly know what all of them are, and when, and wherefore to be used▪ For what are Mastick, Fran­kincense, [Page 114] Olibanum, Ben­zoin, and other like Ro­sins, or Resinous Gums, for their principal and predominant parts, that is, qua Rosins; but Bo­dies resulting from Na­tural, in like manner, as I have shewed, they may be made to result, from Artificial Mixture? That is to say, the O­leous, and Acid parts of Vegetables, being both af­fused and mingled toge­ther, [Page 115] per minima, in some one Vessel of a Plant, they thus incorporate in­to one consistent and fri­able body, which we call Rosin.

Now from hence it is, that the said Rosins, and Resinous Gums; as also Amber and Sulphur for the same reasons; are of so great and ef­fectual Vse against most thin and salt Rheums; sc. as they are Acido­oleous [Page 116] Bodies▪ For by their Acid parts, which in all these Bodies are exceeding copious, they mortifie and refract those salt ones which feed the Rheum. And by their oleous parts, the same salt ones are also Imbi­bed. Whence, they are all, in some degree, in­corporated together; that is, the Rheum is thick­ned: which is the desired effect.

[Page 117] Whereas, on the con­trary, if the Cough pro­ceed not from a thin and especially a salt Rheum, but from a Viscous Flegm; the use of many other Bodies, which are also more oleous, and abound not so much with an Acid as these do, especi­ally some of them, is more proper: such as these, in this case, pro­ving sometimes not only ineffectual, but prejudicial. [Page 118] Since the very Cause of the said Viscousness of Phlegm, is chiefly some great A­cidity in the Blood, or in some other part; as may be proved by divers ar­guments.

Many more Instances might be hereunto subjoyn­ed: and may hereafter be offered to the accep­tance of such, who are inquisitive into matters of this Nature. If I shall not herein anticipate, or [Page 119] reiterate the Thoughts and Observations, of those two accurate and Learned Per­sons Dr. Willis, and Dr. Walter Needham, as to what the one hath alrea­dy published, and both have put us in expecta­tion of. But the Instan­ces already given, are sufficient to evidence what I have said. And, I hope, this present Dis­course to prove, in some measure, thus much; [Page 120] That Experiment, and the Common Notions of Sense are prolifick; and that nothing is barren, but phancy and imagina­tion.

FINIS.

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